ZOE Science & Nutrition

Can Ozempic (semaglutide) solve weight loss?

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Episode notes

A miracle weight loss drug that’s approved in the US and the UK and has few side effects?

Ozempic is going viral on social media. Users are posting dramatic before and after pictures of their weight loss. An Ozempic trend is allegedly blossoming in Hollywood, and famous personalities like Elon Musk claim to have taken it. 

Many remain doubtful, dismissing the craze as just another internet scam preying on people’s insecurities. However, earlier this month - semaglutide - the drug’s active ingredient, was approved as a weight loss treatment by the UK’s National Health Service. Even the most sceptical are taking note.

Jonathan speaks to Dr Robert Kushner the lead investigator of the huge phase 3 clinical trial that evaluated the safety and effectiveness of semaglutide. He is a founder of the American Board of Obesity Medicine and hailed the drug as a ‘game-changer’ in regards to the treatment of obesity.

• Dr Robert Kushner is a Professor of Medicine at Northwestern University and a founder of the American Board of Obesity Medicine. 

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Timecodes:

03:17 – Quickfire questions

04:20 – What is Ozempic, and how does it work?

05:54 – Treating obesity like diabetes

10:24 – The ‘gamechanger’ Semiglutide clinical trial

14:19 – The role our ancestors play in our weight

17:16 – Short-term weight loss vs long-term weight loss

18:40 – Myths about obesity

21:53 – Obesity, a modern problem

23:56 – Other outcomes of the clinical trial

26:59 – The side effects of Semiglutide

31:45 – Risks of using Semiglutide without medical supervision

33:05 – Is Semaglutide linked to cancer?

36:59 – Can you take it If you’re not obese?

39:15 – The long term commitment of Semiglutide

42:49 – Will I put on weight if I stop taking it?

46:01 – Is this the end of obesity

49:30 – Summary

52:28 – Outro

 

Episode transcripts are available here.

Dr. Robert Kushner’s book, Six Factors to Fit: Weight Loss that Works for You!, is available to buy here

Follow Dr. Robert Kushner here 

Studies mentioned: Once-Weekly Semaglutide in Adults with Overweight or Obesity 

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