This One Time On Psychedelics
By Ryan Sprague
Welcome, fellow explorers of the infinite.
If you’re here, it means you’re ready to step beyond the ordinary and into the great unfolding mystery of existence itself. Because psychedelics? They’re not just substances—they’re a doorway to a new way of seeing reality, a lens that reveals the hidden layers of reality we walk through every day. And that’s exactly what we explore here.
I’m Ryan Sprague, and This One Time On Psychedelics isn’t just about trippy stories and wild journeys (though trust me, we have plenty of those). It’s about the conversations that hold the power to awaken us, to shift our consciousness, and to remind us that there is far more to this reality than meets the eye.
These are the conversations that expand hearts, challenge perspectives, and guide us back to the wisdom that has always been within us. Whether through plant medicines, altered states, or the everyday magic woven into life itself, this is a space where we step beyond the known and into the infinite.
The psychedelic renaissance is here. The future is unwritten. And you, my friend, are a part of it.
So buy the ticket. Take the ride. And let’s see how deep this trip goes.
Latest episode
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Ep. 213: It’s Not Goodbye, It’s See Ya Later! (feat. Rachel Varitimos)
Alrighty guys, this episode is extra special to my heart because it’s officially my last episode (for now) on this show before I transition back to the Highly Optimized podcast, my first project that was birthed in 2019 when I chose to start paving m… -

Ep. 212: The Trifecta Of MDMA, Psilocybin & Intramuscular Ketamine (feat. Adam Schell)
One of the main reasons I started this podcast was to showcase the stories, experiences & impact these medicines have made upon people’s lives. That being said, I still get goosebumps when I hear those stories as they remind me of the immense pow… -

Ep. 211: Adventures In Decentralization & Why This Movement Excites Me SO Much (feat. Amethyst Flame)
For anyone with eyes to see, it’s no secret the world is changing at a rapid rate these days. From political hysteria, to new technology emerging almost daily, it’s safe to say that it’s easier than ever to feel overwhelmed while simultaneously doing… -

Ep 210: How The 2018 Farm Bill *Accidentally* Legalized Cannabis (feat. Rand Gifford)
Every episode I do I am excited about, however, this one holds a special place in my heart for a few reasons. First, anytime I get to speak with someone who is as passionate as I am around regenerative agriculture, I geek out like a small school chil… -

Ep. 209: An In Depth Look At How Astrology Has Changed My Life (feat. Rachel Varitimos)
Whenever I have the opportunity to do a podcast with the love of my life, I jump at the opportunity & this week’s episode is no different. Many of you love the episodes here & I do together & our intention with todays episode is to give y… -

Ep. 208: Psychedelic Experiences, Presence & What Really Matters In Life (feat. Seibo Shen)
One of the main reasons I love podcasting so much is, yep, you guessed it, I adore speaking, however, speaking to myself alone in a room is a little weird & definitely not the same experience as when I get to speak to others who stimulate my curi… -

Ep. 207: You Don’t Need A Guru: Here’s How To Heal Yourself (feat. Christopher August)
Whenever today’s guest & I get together, I know it’s going to be an epic conversation. From working together the last two years creating the Breathe With Cannabis brand that many of you have attended already, to traveling to epic places together,… -

Ep. 206: Opening Up To A Brand New World Through Psychedelic Medicines (feat. Kyle Langan)
One of, if not my favorite types of stories I enjoy hearing from the psychedelic space are the stories that come from individuals who, at one point, did not resonate with psychedelic medicines at all. You guys have heard me say before & I’ll say … -

Ep. 205: The Mysteries Of 12 Strand DNA Decoded (feat. Dr. Samuel Lee)
I am sure you guys know what I mean when I say that sometimes I find someone new out there in the world & just cannot get enough of their content & perspective of the world. For me, I take these types of experiences as signs. Signs that perha… -

Ep. 204: Utilizing Psychedelics In The Grieving Process To Heal (feat. Mia Cosco)
One of the areas within the psychedelic space that is extremely important, yet often overlooked, is the ability for these medicines to assist in the process of grief. Grief is something that all of us, no matter what background, ethnicity or age grou…