The Genetics Podcast
EP 181: Transforming frustration into breakthroughs in gene therapy with Salvador Rico of Encoded Therapeutics
Published: 3 April 2025 at 09:25 Europe/London
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Episode notes
This week on The Genetics Podcast, Patrick is joined by Salvador Rico, Chief Medical Officer at Encoded Therapeutics. They discuss Salvador’s journey into drug development, his work on gene therapy for X-linked myotubular myopathy, and fundamental challenges and exciting advances in the genetics field.
Show Notes:
0:00 Intro to The Genetics Podcast
00:59 Welcome to Salvador and how he became involved in drug development
11:01 Frustrations and rewards of the genetics field
13:59 Salvador’s study on gene therapy for patients with X-linked myotubular myopathy (XLMTM)
19:46 Risk of liver issues in gene therapy trials and attempts to mitigate them
24:22 Encoded Therapeutics‘ approach to drug discovery and what motivated Salvador to join the team
27:22 Steps towards therapeutic targeting of gene regulatory elements
30:04 Advantages of different methods for drug delivery
32:31 DNA- versus RNA-based therapy
34:56 Insights from approaches in other fields, including psychiatry
36:35 Considerations for using natural history studies
40:32 Expectations and goals for Encoded Therapeutics’ current and upcoming studies
43:17 Closing remarks
Find out more
Encoded Therapeutics (https://encoded.com/)
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