The Genetics Podcast
EP 138: Personalised medicine using microbiome models with Dr. Almut Heinken
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Episode notes
0:00 Introduction
1:45 Almut’s research experience, including two recent publications on genome-scale metabolic reconstruction human microorganisms
- Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine
- APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple continents, age groups, and body sites
8:00 Implications for personalised medicine and drug discovery using microorganisms in colorectal cancer, inflammatory bowel disease, ulcerative colitis, and more
14:30 Using metabolite and microbiome models to predict the effectiveness of medications
18:00 Differences in microbial communities between various ethnicities, nationalities, and races
24:00 Understanding microbiome community models with the goal of informing drug discovery
26:30 The interplay between diet, the microbiome, and nervous system
28:00 How to use predictive models to understand the diet-microbiome relationship
36:00 Upcoming projects studying the gut microbiome and epigenetics
38:30 Comparing a vaginal birth to a caesarean section on the child’s microbial immunity
40:00 Explaining the cause of heterogeneous differences in monogenic diseases
45:00 Closing remarks
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